Gashaw Andargie Biks, Project HOPE, Ethiopia
Background: The WHO/UNICEF estimates that over 18 million children in low- and middle-income countries, especially in Africa and South-East Asia, are not being vaccinated, with Ethiopia being one of the top four countries contributing to this issue. Objective: To estimate [....] » Read More
Title : Optimizing vaccine trial design: A novel promising zone approach with adaptive Interim analysis for managing delayed effects
Depeng Jiang, University of Manitoba, Canada
Vaccines can exhibit varying delayed effects among individuals, posing challenges in trial design and analysis when using the log-rank test. This can lead to significant power loss and complexities in making interim decisions in adaptive designs. In this presentation, we introduc [....] » Read More
Title : The power of cultural validation when empowering community immunity
Julissa Soto, Julissa Soto Latino Health Equity Consulting, United States
Description of Presentation: Cultural Validation is a critical tool for bridging gaps between public health agencies and the communities they serve. At the onset of the COVID-19 Pandemic, policymakers and public health officials often cited “vaccine hesitancy” as a ke [....] » Read More
Title : Current Investments and Future Directions of Biomedical Advanced Research and Development Authority’s CBRN Vaccines Portfolio
Lindsay Parish, BARDA, United States
The mission of the Biomedical Advanced Research and Development Authority (BARDA) as part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health and Human Services, is to enhance the U.S. government’s capability to respond to chem [....] » Read More
Title : Evaluation of vaccine preventable disease VPD surveillance system in Haryana state, India.
Prasoon Sheoran, Directorate of Health and Family Welfare, India
Background: Case based surveillance is effective in preventing and controlling the incidence of infectious disease. VPD surveillance was first launched in Haryana state of India in 2014. We evaluated the system to identify its strengths and gaps. Methods: A descriptive cross s [....] » Read More
Title : Antibiotic resistance present situation in Bangladesh at different districts
Ismail Hossain, Globe Biotech, Bangladesh
Antibiotic resistance is now a days one of the biggest challenges headed by the health professionals globally, it is causing more quickly due to the misuse and overuse of antibiotics. Bacteria are becoming resistant to commonly used antibiotics and various factors have been ident [....] » Read More
Title : Spatial distribution of zero-dose children in Ethiopia: Evidence for a targeted intervention from a large-scale evaluation survey
Fisseha Shiferie Tadesse, Project HOPE, Ethiopia
Background: Ethiopia is the fourth leading contributor to the global total of zero-dose children (those who lack the first dose of the pentavalent vaccine) and has substantial regional variations in zero-dose children. This study explored the spatial pattern of zero-dose children [....] » Read More
Title : The Ethiopian vaccine supply chain and logistics system’s performance after the last mile delivery initiative: Phenomenological study
Samson Gebremedhin Gebreselassie, Project HOPE, Ethiopia
Background: Uninterrupted availability of potent vaccines requires robust vaccine supply chain and logistics system (VSCLS). With special focus on remote and underserved settings, we assessed the reach and bottlenecks to end-to-end delivery of the Ethiopian VSCLS after the initia [....] » Read More
Title : Limits of vaccine quality control in India: Possible solutions
Bhoj R Singh, Indian Veterinary Research Institute, India
In India, many disease control programs for vaccine-preventable diseases have been running for several decades but such diseases are regularly haunting India. Why? Is it poor vaccine quality, vaccination defect or both? To understand the dilemma we may take the example of the Nat [....] » Read More
Title : Comparative safety, immunogenicity, and efficacy oCEF cell-based and DF-1 cell line adapted infectious bursal disease vaccines in specific-pathogen-free chickens
Daniel Workineh Aynew, Debre Markos University, Ethiopia
Infectious bursal disease (IBD) is an immunosuppressive and economically important disease of young chickens caused by infectious bursal disease virus (IBDV). The National Veterinary Institute (Bishoftu, Ethiopia) produces intermediate IBDV vaccine using primary chicken embryo fi [....] » Read More
Title : In-depth reasons for the high proportion of zero-dose children in underserved populations of Ethiopia: Results from a qualitative study
Gashaw Andargie Biks, Project HOPE, Ethiopia
Background: Increasing attention is being given to reach children who fail to receive routine vaccinations, commonly designated as zero-dose children. A comprehensive understanding of the supply- and demand-side barriers is essential to inform zero-dose strategies in high-bu [....] » Read More
Title : Novel regulatory mechanisms of innate immunity and inflammation
Ping Xie, Associate Professor , United States
Myeloid cells are the major players of innate immunity and inflammation. The functionality of myeloid cells is controlled by innate immune receptor signaling, which is critically regulated by a cytoplasmic adaptor protein termed TRAF3. Ablation of TRAF3 from myeloid cells does no [....] » Read More
Title : The Majority of SARS-CoV-2 Plasma Cells are Excluded from the Bone Marrow Long-Lived Compartment 33 Months after mRNA Vaccination
Doan C Nguyen, Emory University , United States
The goal of any vaccine is to induce long-lived plasma cells (LLPC) to provide life-long protection. Natural infection by influenza, measles, or mumps viruses generates bone marrow (BM) LLPC similar to tetanus vaccination which affords safeguards for decades. Although the SARS-Co [....] » Read More
Title : Immature dendritic cell targeting mRNA vaccine enhances protection from Plasmodium liver stage infection by enhancing T cell responses and antibody titers against CSP repeat regions
Sean Yanik, Johns Hopkins, United States
In 2021, there were 247 million clinical cases and 619,000 deaths from malaria. RTS, S, the first and only WHO approved vaccine for malaria, targets the pre-erythrocytic stage antigen circumsporozoite protein (CSP) and provides only limited efficacy, reducing clinical malaria by [....] » Read More
Title : Designing a conserved, immunogenic, and highly neutralizing vaccine targeting the AMA1-RON2 interaction in P. falciparum
Sean Yanik, Johns Hopkins, United States
In 2022, there were an estimated 249 million clinical cases and 608,000 deaths from malaria. A vaccine against Plasmodium falciparum would provide a critical tool for malaria control and eventual eradication. RTS,S, the first WHO approved vaccine for malaria, targets the antigen [....] » Read More
Title : Natural killer T cells play a significant role in preventing coxsackievirus A10 infection through an adeno-based vaccine expressing enterovirus-like particles
Yen Hung Chow, National Health Research Institutes, Taiwan
Enterovirus A71 (EV-A71) and coxsackievirus A (CVA) were the primary causative agents of hand, foot, and mouth disease (HFMD), the heightened occurrence of HFMD outbreaks associated with CVA10 worldwide has questioned this perspective. Due to the absence of an effective vaccine o [....] » Read More
Title : C. Freundii- Associated osteomyelitis and thromboembolic events following moderna COVID-19 vaccination: A rare case report from Nepal
Subodh Adhikari, Maharajgung Medical Campus, Nepal
Introduction: Vaccination against Coronavirus Disease 2019 (COVID-19) is essential for controlling the ongoing cases of this disease. Citrobacter infections of the bones and joints are extremely uncommon. Thromboembolism and deep vein thrombosis are very rare complications. Ca [....] » Read More
Title : Continued COVID-19 Vaccine Uncertainty in the United States in the Post-Pandemic Era
Hallie Cope, Ipsos, United States
The production, distribution and administration of the COVID-19 vaccines was pivotal in changing the course of the pandemic; however, relative uptake of the vaccines varied across regions. The Ipsos Global Core Vaccines Study is a multi-country, multi-centre, online, consumer [....] » Read More
Title : Water Quality and Environmental Analysis of Shrines in Karachi
Anosha Nangraj, Habib University, Pakistan
Safe and readily available water is integral for public health. Karachi (Pakistan), ranked number 11 as the most populous metropolitan city in the world, is heavily impacted by the critical issue of water contamination. Shrines in Karachi, do not only serve as a place of worship [....] » Read More