Vaccines for Immunocompromised Individuals

Developing vaccines for immunocompromised individuals presents unique challenges due to their reduced ability to mount strong immune responses. Conditions such as HIV, cancer, and post-transplant therapies often lead to immune suppression, making standard vaccination protocols less effective. Tailored strategies are essential—these may include altered dosing regimens, booster schedules, or the use of non-replicating platforms to enhance safety and efficacy. Instead of live-attenuated vaccines, which may pose risks, inactivated or subunit-based options are generally preferred. Advances in immunodiagnostics are also contributing to better patient-specific planning, allowing for closer monitoring of response and refinement of vaccine timing. As global health initiatives strive for inclusive protection, designing reliable immunization pathways for immunocompromised individuals remains crucial to safeguarding this high-risk population and minimizing preventable disease burdens.